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  11. Icariin, Astragaloside A And Puerarin Mixture Attenuates Cognitive Impairment In App/ps1 Mice Via Inhibition Of Ferroptosis-lipid Peroxidation

Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation

Tian-Ci Zhang1, Yi-Can Lin1, Ning-Ning Sun1

  • 1Hebei University of Chinese Medicine, Hebei Key Laboratory of Chinese Medicine Research On Cardio-cerebrovasc, Hebei, Shijiazhuang, 050091, China.

Neurochemistry International
|February 27, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

This study shows that the YHG mixture effectively reduces ferroptosis and lipid peroxidation in an Alzheimer

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting elderly quality of life.
  • The exact pathogenesis of AD remains unclear, but ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, is implicated.
  • Targeting lipid peroxidation in ferroptosis presents a potential therapeutic strategy for AD.

Purpose of the Study:

  • To investigate the effects of a standardized herbal mixture (YHG) on ferroptosis and lipid peroxidation in a mouse model of Alzheimer's disease.
  • To explore the underlying molecular mechanisms of YHG's action in ameliorating AD pathology.

Main Methods:

  • Utilized APP/PS1 transgenic mice as an Alzheimer's disease model.
  • Conducted behavioral tests, iron level detection, Transmission Electron Microscopy (TEM), lipid peroxidation assays, and antioxidant capacity measurements.
Keywords:
Alzheimer's diseaseAstragaloside AAstragaloside IV (Pubchem CID: 13943297)Ferroptosis-lipid peroxidation

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  • Performed immunofluorescence, Western blot, and real-time qPCR to analyze protein and gene expression.

    • Main Results:

    • YHG treatment improved cognitive behaviors and hippocampal neuron ultrastructure in APP/PS1 mice.
    • YHG reduced iron, malondialdehyde (MDA), and lipid peroxide (LPO) levels while increasing superoxide dismutase (SOD) and reduced glutathione (GSH) in brain and serum.
    • YHG modulated key ferroptosis-related proteins, upregulating SLC7A11, SLC3A2, and GPX4, and downregulating ACSL4 and LPCAT3.

    Conclusions:

    • YHG demonstrates therapeutic potential for Alzheimer's disease by inhibiting ferroptosis and lipid peroxidation.
    • The mechanism involves regulating the expression of proteins crucial to the ferroptosis pathway.
    • YHG may offer a novel approach to managing cognitive dysfunction in Alzheimer's disease.
    Iacriin (Pubchem CID: 5318997)
    Icariin
    Puerarin
    Puerarin (Pubchem CID: 5281807)