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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
[Update: Heart Failure with Preserved Ejection Fraction]
Caroline Morbach1, Stefan Störk1
1Medizinische Klinik und Poliklinik I, Deutsches Zentrum für Herzinsuffizienz, Universitätsklinikum Würzburg, Würzburg, Germany.
Insights
Diagnosing and treating heart failure with preserved ejection fraction (HFpEF) is complex. Recent guidelines and phenogroup classifications offer a path toward personalized therapies for HFpEF patients, improving outcomes.
Area of Science:
- Cardiology
- Heart Failure Research
Abstract:
Heart failure with a preserved ejection fraction (HFpEF) is a multifaceted disease entity. Confirming the diagnosis as well as tailoring the most appropriate therapy remains an ongoing challenge. The 2021 heart failure guidelines of the European Society of Cardiology (ESC) suggested a simplified diagnostic approach, and the guideline update provided in 2023 gave recommendations regarding pharmacotherapy based on recent evidence. Further, the Heart Failure Association (HFA) and the European Heart Rhythm Association of the ESC jointly proposed a scheme how to classify HFpEF patients into phenogroups of distinct pathophysiology that may benefit from individually targeted treatment. Regarding HFpEF originating from secondary causes, e.g. M. Fabry, amyloidosis or hypertrophic cardiomyopathy, there are emerging therapeutic options with the potential to substantially improve the physical capacity, quality of life and prognosis in these patients. The here presented update gives an overview on the recent advances in the area of HFpEF.
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