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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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[Retard chronic kidney disease progression]

Max Schuller1, Turgay Saritas2

  • 1Abteilung für Nephrologie, Universitätsklinikum Innere Medizin, Medizinische Universität Graz, Graz.

Deutsche Medizinische Wochenschrift (1946)
|February 27, 2024
PubMed

Insights

New treatments like SGLT2 inhibitors and Finerenon offer hope for slowing chronic kidney disease (CKD) progression. These therapies, alongside blood pressure management, help mitigate cardiovascular risks in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Context:

  • Chronic kidney disease (CKD) is a significant global health issue.
  • CKD is staged by estimated glomerular filtration rate (eGFR) and albuminuria.
  • Therapeutic options for CKD have recently expanded.

Purpose:

  • To outline current therapeutic strategies for slowing CKD progression.
  • To highlight the role of blood pressure control in CKD management.
  • To introduce novel pharmacotherapies for CKD and associated cardiovascular risks.

Summary:

  • CKD management involves targeting specific blood pressure goals (<130/80mmHg or <140/90mmHg based on patient factors).
  • Renin-angiotensin-system inhibitors (RASi) and sodium-glucose-cotransporter 2 inhibitors (SGLT2i) form the cornerstone of CKD therapy.
  • SGLT2 inhibitors are broadly applicable for CKD with eGFR >20ml/min/1.73m2, with treatment continuation recommended until dialysis.
  • Finerenon presents a new therapeutic avenue for diabetic nephropathy (ACR >30mg/g, eGFR >25ml/min/1.73m2), demonstrating efficacy in slowing disease progression and reducing cardiovascular events.

Impact:

  • Expanded therapeutic options offer improved management of CKD progression.
  • Novel agents like Finerenon show promise in reducing cardiovascular events in specific CKD populations.
  • Optimized blood pressure control and pharmacotherapy can mitigate the substantial global burden of CKD.

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