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Updated: Jul 2, 2025

Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking
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Using an α-Bungarotoxin Binding Site Tag to Study GABA A Receptor Membrane Localization and Trafficking

Published on: March 28, 2014

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Extrasynaptic Localization Is Essential for α5GABAA Receptor Modulation of Dopamine System Function

Alexandra M McCoy1,2, Thomas D Prevot3,4, Md Yeunus Mian5

  • 1Department of Pharmacology and Center for Biomedical Neuroscience, UT Health San Antonio, San Antonio, Texas 78229 mccoya1@livemail.uthscsa.edu.

Eneuro
|February 27, 2024
PubMed
Summary

Extrasynaptic alpha5-GABA(A) receptors (GABAAR) are crucial for the drug GL-II-73 to modulate dopamine system function in psychosis models. Shifting these receptors to the synapse blocks GL-II-73

Keywords:
GABAdopamineelectrophysiologypsychosisradixinrat

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