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Uric acid levels and heart failure: A mendelian randomization study

Jiaqi Zheng1, Kaiwen Cen1, Jiajun Zhang1

  • 1School of Public Health, Shenyang Medical College, Shenyang, 110034, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|February 27, 2024
PubMed

Insights

Elevated uric acid levels may increase heart failure risk. This study used Mendelian randomization to analyze genetic data, suggesting a potential causal link between higher uric acid and heart failure development.

Area of Science:

  • Cardiovascular Science
  • Metabolic Health
  • Genetic Epidemiology

Background:

  • Uric acid is the final product of purine metabolism.
  • Associations between uric acid and cardiovascular/cerebrovascular diseases are studied.
  • The specific link between uric acid and heart failure is not fully understood.

Purpose of the Study:

  • To investigate the potential causal relationship between uric acid levels and heart failure.
  • To utilize genome-wide association study data for a robust analysis.

Main Methods:

  • Two-sample Mendelian randomization (MR) analysis was performed.
  • Inverse variance weighted (IVW) method was the primary analysis technique.
  • Sensitivity analyses included MR-Egger, weighted median (WME), and MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO).

Main Results:

  • The IVW analysis indicated a possible causal link between higher uric acid levels and increased heart failure risk (OR: 1.09, 95% CI: 1.01-1.17, P < 0.05).
  • Sensitivity analyses (MR-Egger, WME) supported the IVW findings.
  • No significant pleiotropy was detected by MR-PRESSO, confirming result stability.

Conclusions:

  • The study findings suggest that elevated uric acid levels may be a contributing factor to an increased risk of heart failure.
  • The results are robust, supported by multiple sensitivity analyses.
  • Further research may explore therapeutic strategies targeting uric acid to mitigate heart failure risk.
Abstract

Keywords:
Causal effectsHeart failureMendelian randomizationUric acid

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