Exploring the reported adverse effects of COVID-19 vaccines among vaccinated Arab populations: a multi-national survey study
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View abstract on PubMed
Summary
This summary is machine-generated.COVID-19 vaccine adverse events (AEs) were common, particularly local reactions and pain, across six Arabic countries. Older age and male gender were associated with increased AEs after the first dose.
Area Of Science
- Public Health
- Epidemiology
- Vaccinology
Background
- The COVID-19 pandemic presented significant global health challenges, necessitating widespread vaccination efforts.
- Concerns regarding the safety and adverse events (AEs) of COVID-19 vaccines have emerged.
- Understanding vaccine AEs is crucial for maintaining public trust and vaccine uptake.
Purpose Of The Study
- To investigate the incidence and types of adverse events following COVID-19 vaccination.
- To identify factors associated with the occurrence of adverse events.
- To assess the risk of post-vaccination COVID-19 disease with different vaccine types.
Main Methods
- A cross-sectional study involving 1564 participants was conducted in six Arabic countries between January 1-22, 2022.
- A validated, self-administered Arabic questionnaire collected sociodemographic data, vaccination history, and experienced AEs.
- Multistage sampling was employed, including random selection of governorates and urban/rural areas within each country.
Main Results
- Local AEs were most frequent after the first (67.9%), second (46.6%), and third (45.7%) doses. Bone pain, myalgia, and fever were also common.
- Johnson and Johnson, Sputnik Light, and Moderna vaccines showed higher AE frequencies.
- Increased age (61-75 years) and male gender were associated with higher odds of AEs after the first dose.
- Sinovac, Sinopharm, and Johnson and Johnson vaccines were associated with higher rates of post-vaccination COVID-19.
- Pre-vaccination SARS-CoV-2 infection significantly increased the risk of post-vaccination COVID-19 across all doses.
Conclusions
- Adverse events following COVID-19 vaccination are common, with local reactions being the most prevalent.
- Specific vaccines (Johnson and Johnson, Sputnik Light, Moderna) were associated with a higher frequency of AEs.
- Factors like age, gender, and prior infection influence AE occurrence and post-vaccination disease risk.
- Further research is needed to provide more generalizable data on the safety of various COVID-19 vaccines.
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