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Development of spray-dried powder hand sanitiser with prolonged effectivity
Lucie Večerková1, Lucie Mašková1, Zdeněk Knejzlík2
1Department of Chemical Engineering, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.
Scientific Reports
|February 27, 2024
Summary
New chitosan carriers offer sustained antibacterial protection, overcoming the limitations of traditional hand sanitizers. These micro-particles provide long-lasting hygiene and comfort without skin irritation.
Area of Science:
- Materials Science
- Pharmaceutical Technology
- Microbiology
Background:
- Hand sanitizers are crucial for hygiene but have limitations like short-term effects and skin irritation.
- Frequent application and potential adverse effects necessitate improved disinfection methods.
Purpose of the Study:
- To develop and evaluate novel chitosan-based carriers for sustained release of chlorhexidine digluconate.
- To assess the efficacy and user experience of these micro-particles compared to conventional disinfectants.
Main Methods:
- Spray-drying technique used to create swellable chitosan carriers.
- Encapsulation of chlorhexidine digluconate as the active antibacterial agent.
- In vitro testing against E. coli and S. epidermidis, and in vivo evaluation with human volunteers.
Main Results:
- Successfully prepared micron-sized chitosan particles (<10 µm) for sustained antibacterial release.
- Formulations demonstrated comparable or superior efficacy to commercial disinfectants.
- User evaluation indicated comfort and non-recognition by skin receptors.
Conclusions:
- Spray-dried chitosan carriers offer a promising alternative to traditional hand sanitizers.
- The sustained release mechanism enhances protection and minimizes skin irritation.
- The developed micro-particles are effective, comfortable, and suitable for long-term personal hygiene.
