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Testosterone bounce predicts favorable prognoses for prostate cancer patients treated with degarelix
Shuhei Kamada1, Shinichi Sakamoto1, Ryo Kinoshita1
1Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
The Prostate
|February 27, 2024
Summary
Testosterone bounce, a rise in testosterone levels after initial suppression, is a promising biomarker for predicting overall survival and cancer-specific survival in prostate cancer patients treated with degarelix acetate.
Area of Science:
- Oncology
- Endocrinology
Background:
- Investigating the clinical significance of testosterone (T) level fluctuations during degarelix acetate therapy for prostate cancer.
- Establishing a cut-off level of 20 ng/dL for T to predict treatment outcomes.
Purpose of the Study:
- To evaluate the predictive value of testosterone dynamics, including T bounce, for survival outcomes in prostate cancer patients.
- To clarify the role of T levels as prognostic factors in patients receiving degarelix acetate.
Main Methods:
- Retrospective analysis of 120 prostate cancer patients treated with degarelix acetate.
- Evaluation of nadir T levels, max T levels, and T bounce (nadir T < 20 ng/dL and max T ≥ 20 ng/dL) as predictors.
- Assessment of overall survival (OS), cancer-specific survival (CSS), and progression-free survival (PFS).
Main Results:
- T bounce occurred in 50% of patients (60/120).
- T bounce was significantly associated with favorable OS (p=0.0019) and CSS (p=0.0013), but not PFS (p=0.92).
- In a subgroup analysis, T bounce predicted favorable OS and CSS after biochemical recurrence.
Conclusions:
- Testosterone bounce, defined by specific T level thresholds, is a promising biomarker for predicting OS and CSS.
- This finding is particularly relevant for prostate cancer patients undergoing treatment with degarelix acetate.
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