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Published on: June 16, 2023
Mitochondrial derived vesicles- Quo Vadis?
Reut Hazan Ben-Menachem1, Ophry Pines1, Ann Saada2,3,4
1Department of Molecular Genetics and Microbiology, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Abstract:
Mitochondria are dynamic, intracellular organelles with a separate genome originating from prokaryotes. They perform numerous functions essential for cellular metabolism and energy production. Mitochondrial-derived vesicles (MDVs) are single or double membrane-enclosed vesicles, formed and released from the mitochondrial sub-compartments into the cytosol, in response to various triggers. MDVs interact with other organelles such as lysosomes and peroxisomes or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse protein and lipid cargoes and are involved in various functions such as mitochondrial quality control, immunomodulation, energy complementation, and compartmentalization and transport. This review aims to provide a summary of the current knowledge of MDVs biogenesis, release, cargoes, and roles.
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