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Association between stroke and venous leg ulcers: A Mendelian randomization study.
Ruiye Xie1, Zhengyun Han1, Guoqing Liu1
1Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
International Wound Journal
|February 28, 2024
Summary
This study found no causal link between stroke and venous leg ulcers (VLUs). Treatments for stroke are unlikely to be effective for preventing or treating VLUs.
Area of Science:
- Cardiovascular Science
- Dermatology
- Genetics
Background:
- Venous leg ulcers (VLUs) are chronic wounds with significant morbidity.
- Stroke is a leading cause of disability and mortality worldwide.
- Understanding potential links between stroke and VLUs is crucial for patient care.
Purpose of the Study:
- To investigate potential bidirectional causal relationships between stroke and venous leg ulcers (VLUs).
- To determine if stroke influences VLU development or if VLUs increase stroke risk.
Main Methods:
- A two-sample Mendelian randomization (MR) analysis was employed.
- Genetic variants associated with stroke were used as instrumental variables to assess VLU risk.
- Inverse Variance Weighted (IVW), Weighted Median, MR-Egger, and weighted mode methods were utilized for analysis.
Main Results:
- No statistically significant causal association was found between stroke and VLUs across all applied MR methods.
- The Inverse Variance Weighted method showed no association (p=0.9095).
- Consistent results were observed with Weighted Median (p=0.6223), MR-Egger (p=0.9691), and weighted mode (p=0.6089) analyses.
Conclusions:
- This Mendelian randomization study indicates no causal relationship between stroke and venous leg ulcers.
- Current evidence does not support a direct causal link in either direction.
- Therapeutic strategies targeting stroke are unlikely to impact VLU incidence or management.
