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Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis

Hua Zhao¹, Xiao-Hong Jiang¹, Qiu-Pin Huang¹

¹Geriatrics Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Archives of Medical Science : AMS

|February 28, 2024

Abstract

Introduction:

Given the evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between genetic polymorphisms in MMP genes and COPD risk. However, reliable measures of these results are lacking.

Material And Methods:

We assessed the published evidence for association of the MMP-3, MMP-9 and MMP-12 polymorphisms with COPD risk using meta-analytic techniques. The odds ratio (OR) and 95% confidence interval (CI) were calculated for each study using fixed or random effect models.

Results:

A total of 23 case-control studies were included in the meta-analysis. No significant association was observed between the MMP-9 rs3918242 polymorphism and COPD risk in the overall populations under the dominant (T/T + C/T vs. C/C: OR = 1.30, 95% CI: 1.00-1.69, p = 0.054) and allele contrast (T allele vs. C allele: OR = 1.22, 95% CI: 0.97-1.53, p = 0.088) models. However, in sub-group analysis the polymorphism rs3918242 was significant in Asians under the dominant model (T/T + C/T vs. C/C: OR = 1.66, 95% CI: 1.02-2.72, p = 0.043). The results for MMP-12 rs2276109 showed an association with COPD only in mixed populations (G/G + A/G vs. A/A: OR = 1.57, 95% CI: 1.10-2.24, p = 0.013; G allele vs. A allele: OR = 1.52, 95% CI: 1.09-2.14, p = 0.015). We did not find any significant association of the MMP-12 rs652438 and MMP-3 rs35068180 polymorphisms with COPD.

Conclusions:

The findings of this meta-analysis suggest that there is a risk of COPD associated with the MMP-9 rs3918242 and MMP-12 rs2276109 polymorphisms in certain ethnic groups.

Insights

Genetic variations in matrix metalloproteinases (MMPs) like MMP-9 and MMP-12 are linked to chronic obstructive pulmonary disease (COPD) risk in specific ethnic groups. This meta-analysis highlights potential genetic associations for COPD pathogenesis.

Area of Science:

Genetics
Pulmonology
Biochemistry

Background:

Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD).
Previous case-control studies have investigated the association between MMP gene polymorphisms and COPD risk.
Reliable measures of these associations are currently lacking.

Purpose of the Study:

To conduct a meta-analysis assessing the published evidence for associations between MMP-3, MMP-9, and MMP-12 polymorphisms and COPD risk.
To provide reliable measures of these genetic associations using meta-analytic techniques.

Main Methods:

A meta-analysis of 23 case-control studies was performed.
Odds ratios (OR) and 95% confidence intervals (CI) were calculated for MMP-3, MMP-9, and MMP-12 polymorphisms.
Fixed or random effect models were used to analyze the data.

Main Results:

No significant association was found between MMP-9 rs3918242 polymorphism and COPD risk in overall populations.
MMP-9 rs3918242 polymorphism showed a significant association with COPD risk in Asian populations (dominant model).
MMP-12 rs2276109 polymorphism was associated with COPD risk in mixed populations (dominant and allele contrast models).
No significant association was found for MMP-12 rs652438 and MMP-3 rs35068180 polymorphisms with COPD.

Conclusions:

The meta-analysis suggests that MMP-9 rs3918242 and MMP-12 rs2276109 polymorphisms may confer a risk for COPD in specific ethnic groups.
These findings contribute to understanding the genetic factors influencing COPD development.

Read full analysis

Keywords:

chronic obstructive pulmonary disease gene polymorphisms matrix metallopeptidases meta-analysis

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