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Related Concept Videos

Precipitation Titration: Endpoint Detection Methods01:19

Precipitation Titration: Endpoint Detection Methods

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In argentometric precipitation titrations, endpoints can be detected visually by the Mohr, Volhard, and Fajans methods. In the Mohr method, adding a soluble chromate indicator gives an initial yellow color to the analyte solution. As the titrant is added, the first excess of silver ions forms a red silver chromate precipitate, marking the endpoint. The solution pH should be maintained at about 8 by adding solid CaCO3.
In the Volhard method, a standard excess of AgNO3 is first added to the...
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Updated: Jul 2, 2025

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
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Uric acid quantification via colorimetric detection utilizing silver oxide-modified activated carbon nanoparticles

Umar Nishan1, Ateeq Ahmed1, Nawshad Muhammad2

  • 1Department of Chemistry, Kohat University of Science and Technology Kohat 26000 KP Pakistan umarnishan85@gmail.com amirqau@yahoo.com.

RSC Advances
|February 28, 2024
PubMed
Summary

A new silver oxide-doped activated carbon nanoparticle sensor accurately detects uric acid (UA) in low concentrations. This colorimetric platform offers a sensitive and selective method for diagnosing UA-related diseases.

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Area of Science:

  • Nanomaterials Science
  • Analytical Chemistry
  • Biomedical Sensing

Background:

  • Uric acid (UA) is a critical health biomarker linked to gout, kidney stones, and renal failure.
  • Elevated UA levels in joints cause chronic pain and tissue damage.
  • Developing sensitive and selective UA detection methods is crucial for early disease diagnosis.

Purpose of the Study:

  • To synthesize and characterize a novel silver oxide-doped activated carbon nanoparticle (NPs) assembly.
  • To develop a colorimetric sensing platform for the quantitative detection of uric acid.
  • To optimize and validate the performance of the developed UA sensor.

Main Methods:

  • Silver oxide-doped activated carbon NPs were synthesized using a salt-melting approach.
  • The nanomaterial was functionalized with an ionic liquid for enhanced sensing capabilities.
  • Colorimetric detection of UA was achieved using UV-vis spectroscopy and naked-eye observation.

Main Results:

  • The synthesized nanocomposite was confirmed via UV-vis, FTIR, XRD, SEM, and EDX.
  • A distinct color change from blue-green to colorless indicated UA presence.
  • Optimized conditions yielded a linear detection range of 0.001-0.36 μM with high linearity (R²=0.999).
  • The sensor demonstrated excellent sensitivity with limits of detection and quantification at 0.207 and 0.69 nM, respectively.
  • The sensor showed high selectivity, unaffected by common potential interferents.

Conclusions:

  • The developed silver oxide-doped activated carbon NP sensor is a highly sensitive, selective, and cost-effective platform for uric acid detection.
  • This colorimetric sensor holds significant potential for clinical diagnostics of UA-associated conditions.
  • The optimized sensor provides a reliable tool for monitoring uric acid levels in biological samples.