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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

366
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Allograft Function Predicts Mortality In Kidney Transplant Recipients With Severe Covid-19: A Paradoxical Risk Factor

Allograft function predicts mortality in kidney transplant recipients with severe COVID-19: a paradoxical risk factor

Han Luo1,2, Jingyu Wen3, Hongji Yang1,2,4

  • 1Department of Organ Transplantation, Sichuan Provincial Peoples Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Immunology
|February 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Kidney transplant recipients with poorer pre-infection kidney function faced significantly higher mortality from severe COVID-19. Maintaining adequate allograft function is crucial for improving outcomes in these immunocompromised patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Kidney transplant recipients (KTRs) are vulnerable to severe COVID-19 due to immunosuppression.
  • The impact of pre-existing allograft function on severe COVID-19 outcomes in KTRs remains understudied.

Purpose of the Study:

  • To investigate the association between pre-infection allograft function and the prognosis of severe COVID-19 in kidney transplant recipients.

Main Methods:

  • Retrospective cohort study of 82 KTRs with severe COVID-19.
  • Patients categorized into decreased and normal estimated glomerular filtration rate (eGFR) groups based on pre-infection allograft function.
  • Logistic regression and nomogram used to identify mortality risk factors.

Main Results:

Keywords:
allograft functioncreatinineestimated glomerular filtration ratekidney transplant recipient

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Mouse Kidney Transplantation: Models of Allograft Rejection
16:15

Mouse Kidney Transplantation: Models of Allograft Rejection

Published on: October 11, 2014

20.6K
Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

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Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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  • Higher mortality observed in KTRs with decreased pre-infection eGFR (31.25%) compared to normal eGFR (8.00%) (P=0.006).
  • Pre-infection allograft insufficiency and high mycophenolic acid dosage (>1500 mg/day) were independent risk factors for death.
  • Nirmatrelvir/ritonavir use showed a protective effect against mortality (OR=0.15).

Conclusions:

  • Pre-infection allograft function is a significant predictor of mortality in KTRs with severe COVID-19.
  • Allograft function improved post-treatment for severe COVID-19, unlike in non-severe cases.
severe COVID-19