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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Plasmablastic lymphoma: current knowledge and future directions.

Ji-Wei Li¹, Hong-Ling Peng², Xiao-Yan Zhou^3,4,5

¹Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, China.

Frontiers in Immunology

|February 28, 2024

Summary

This summary is machine-generated.

Plasmablastic lymphoma (PBL) is an aggressive cancer. This review summarizes current knowledge on PBL, including its features, molecular profile, and treatment strategies for better patient outcomes.

Keywords:

HIV immunotherapy molecular profiles plasmablastic lymphoma treatment

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Published on: October 19, 2014

Area of Science:

Hematology
Oncology
Immunology

Background:

Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma.
PBL is strongly associated with HIV infection and immunodeficiency but also occurs in immunocompetent individuals.
PBL exhibits distinct clinical, pathological, and molecular features.

Purpose of the Study:

To review the epidemiology of PBL.
To summarize clinical, pathological, and molecular features of PBL.
To discuss diagnostic and therapeutic strategies for PBL.

Main Methods:

Literature review of studies on Plasmablastic lymphoma.
Analysis of clinical and pathological data.
Review of molecular profiling studies, including gene expression analysis.

Main Results:

PBL shows plasmablastic morphology and plasma cell marker expression.
Clinicopathologic features differ between HIV-positive and HIV-negative patients.
Frequent c-MYC rearrangement and BCR signaling pathway downregulation are key molecular findings.

Conclusions:

PBL is an aggressive lymphoma with unique characteristics.
Understanding molecular features aids in diagnosis and treatment.
Despite advances, PBL prognosis remains poor, necessitating novel therapeutic approaches.