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Albumin-bilirubin score is a useful predictor of worsening liver reserve after stereotactic body radiation therapy in elderly Japanese patients with hepatocellular carcinoma

  • 0Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Journal of Radiation Research +

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February 28, 2024

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February 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The baseline albumin-bilirubin (ALBI) score effectively predicts worsening liver reserve in hepatocellular carcinoma (HCC) patients after stereotactic body radiation therapy (SBRT). This finding aids in managing HCC prognosis and treatment planning.

Area Of Science

  • Hepatobiliary Oncology
  • Radiation Oncology
  • Biomarker Research

Background

  • Hepatocellular carcinoma (HCC) prognosis depends on liver reserve.
  • Child-Pugh (CP) score is traditional but limited for assessing liver reserve capacity.
  • Albumin-bilirubin (ALBI) score offers a more precise measure of liver reserve in HCC.

Purpose Of The Study

  • To evaluate the role of the ALBI score in predicting liver reserve changes post-stereotactic body radiation therapy (SBRT) for HCC.
  • To compare ALBI score's predictive power against the CP score.
  • To assess the clinical utility of baseline ALBI score for HCC patients undergoing SBRT.

Main Methods

  • Retrospective analysis of 42 HCC patients treated with SBRT (CyberKnife).
  • Assessment of liver reserve using ALBI and CP scores before and after SBRT.
  • Statistical analysis (univariate and multivariate) to identify predictors of worsening liver reserve.

Main Results

  • 1-year overall survival (OS), local control (LC), and progression-free survival (PFS) were 100%, 98%, and 62%, respectively.
  • Baseline ALBI score (≥-2.7 vs <-2.7) was the sole significant predictor of worsening liver reserve post-SBRT.
  • While OS and LC were favorable, poor PFS necessitates further treatment strategies for recurrent HCC.

Conclusions

  • The baseline ALBI score is a valuable and significant predictor of liver reserve capacity following SBRT in HCC patients.
  • The ALBI score aids in identifying patients at higher risk of liver reserve deterioration.
  • Accurate prediction of post-SBRT liver reserve is crucial for optimizing HCC management and patient outcomes.

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