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Discussion on the Influence of Gpx 4 Target in the Field of Cancer

Ya-Lan Wang1, Hong-Yan Guo1, Tong Zhou1

  • 1Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain, Affiliated Ministry of Education, College of Pharmacy, Yanbian University, Yanji, Jilin, 133002, China.

Current Medicinal Chemistry
|February 28, 2024
PubMed

Insights

This review summarizes research on glutathione peroxidase 4 (Gpx4) inhibitors and their role in ferroptosis. Gpx4 is a key indicator for tumor occurrence and a target for cancer treatment development.

Area of Science:

  • Biochemistry
  • Oncology
  • Pharmacology

Background:

  • Glutathione peroxidase 4 (Gpx4) is crucial in regulating ferroptosis, a form of programmed cell death.
  • Gpx4 activity is linked to tumor development and progression, making it a potential therapeutic target.
  • While no Gpx4 inhibitors are currently marketed, significant research is ongoing, with some compounds in clinical trials.

Purpose of the Study:

  • To consolidate existing data on Gpx4 inhibitors and associated regulatory proteins.
  • To provide a comprehensive overview of the current research landscape for Gpx4 inhibitors.
  • To offer new insights for developing effective, low-toxicity Gpx4 inhibitors for cancer therapy.

Main Methods:

  • Systematic literature review of studies on Gpx4 inhibitors.
  • Analysis of regulatory proteins interacting with Gpx4.
  • Compilation of data on compounds that have entered clinical research.

Main Results:

  • Identification of key regulatory proteins involved in Gpx4 function.
  • Summary of various Gpx4 inhibitors and their mechanisms of action.
  • Overview of the progress of Gpx4 inhibitor clinical research.

Conclusions:

  • Gpx4 is a promising biomarker and therapeutic target for various cancers.
  • Further research is needed to develop efficient and safe Gpx4 inhibitors.
  • This review can guide future efforts in Gpx4-targeted cancer treatment strategies.
Keywords:
Gpx4cancercervical canceferroptosisinhibitorreactive oxygen species.

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