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The Role of Beclin 1 and HER2 in Colorectal Carcinoma; An Immunohistochemical Study
Marwa Salah Gadallah1, Marwa Dawood1, Asmaa Abdou1
1Department of Pathology, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt.
Asian Pacific Journal of Cancer Prevention : APJCP
|February 28, 2024
Summary
Beclin 1 expression is elevated in colorectal cancer (CRC) tissues compared to adenomas. High HER2 expression in CRC correlates with poor prognosis and shorter survival, indicating its role in cancer progression.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Pathology
Background:
- Colorectal cancer (CRC) is a significant global health concern.
- Understanding molecular markers like Beclin 1 and HER2 is crucial for diagnosis and prognosis.
Purpose of the Study:
- To compare Beclin 1 and HER2 protein expression in CRC versus colonic adenoma.
- To correlate their expression with clinicopathological features and patient survival in CRC.
Main Methods:
- Immunohistochemistry was used to analyze Beclin 1 and HER2 expression.
- Paraffin-embedded tissues from 17 adenoma and 81 CRC cases were studied.
Main Results:
- Cytoplasmic Beclin 1 expression was higher in CRC than adenoma (P=0.051).
- High Beclin 1 correlated with distal colon location (P=0.028).
- High HER2 expression was linked to vascular invasion (P=0.05), perineural invasion (P=0.03), and reduced overall survival (P=0.035).
Conclusions:
- Beclin 1 expression suggests a role in colorectal carcinogenesis.
- HER2 expression indicates a poor prognostic factor in colorectal cancer patients.
