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Necrotising soft tissue infections

Ingunn Margareetta Gundersen1, Trond Bruun1, Stian Kreken Almeland2

  • 1Seksjon for infeksjonssjukdommar, Medisinsk klinikk, Haukeland universitetssjukehus, og, Klinisk institutt 2, Det medisinske fakultet, Universitetet i Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|February 28, 2024
PubMed

Insights

Necrotising soft tissue infections are severe, rapidly spreading conditions requiring prompt surgical and antibiotic treatment. Early diagnosis is critical for improving patient outcomes and reducing high morbidity and mortality rates associated with these infections.

Area of Science:

  • Infectious Diseases
  • Surgical Pathology
  • Dermatology

Background:

  • Necrotising soft tissue infections (NSTIs) are severe bacterial infections affecting skin, subcutaneous tissue, fascia, and musculature.
  • These infections spread rapidly, leading to extensive tissue loss, high morbidity, and mortality.
  • Despite their severity, prospective clinical trials on NSTI treatment are limited.

Conclusions:

  • Prompt diagnosis and aggressive surgical intervention are essential for managing necrotising soft tissue infections.
  • Targeted antibiotic therapy plays a crucial role in controlling infection spread and improving patient survival.
  • Further prospective studies are needed to clarify optimal treatment protocols for NSTIs.

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