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Related Experiment Video

Updated: Jul 2, 2025

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience
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Temporal transcriptomic dynamics in developing macaque neocortex.

Longjiang Xu1, Zan Yuan2,3, Jiafeng Zhou2,4

  • 1Institute of Medical Biology Chinese Academy of Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China.

Elife
|February 28, 2024
PubMed
Summary

Researchers mapped gene expression during primate neocortical development. They identified distinct cell types and signaling pathways, revealing how neural stem cells differentiate into specific neuron types during primate brain formation.

Keywords:
developmental biologymacaque cortexneural progenitorneuroscienceprenatal neurogenesisrhesus macaquescRNA-seq

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Area of Science:

  • Developmental Neuroscience
  • Transcriptomics
  • Primate Brain Development

Background:

  • Understanding neocortical neurogenesis in humans and primates is limited, despite extensive mouse studies.
  • Rhesus macaque cortical development models human development, including neural stem cell composition and supragranular layer thickness.

Conclusions:

  • This study provides a comprehensive overview of gene expression patterns during primate neocortex layer formation.
  • It elucidates the temporal dynamics of radial glial progenitor differentiation and cell fate determination.
  • Findings highlight the roles of BMP, FGF, and WNT signaling in distinguishing vRG and oRG lineages.