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Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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Related Experiment Video

Updated: May 9, 2026

Microbiologically Induced Calcite Precipitation Mediated by Sporosarcina pasteurii

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Published on: April 16, 2016

Microbially Inspired Calcium Carbonate Precipitation Pathway Integrated Polyelectrolyte Capsules (MICPC) for

Hao Yuan¹, Lufan Jia¹, Xin Xie¹

¹School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, 610031, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)

|February 28, 2024

Summary

New polyelectrolyte capsules incorporating calcium carbonate precipitation pathways offer stable, controlled drug and vaccine delivery. This breakthrough overcomes burst release issues, enabling tunable and sustained biomolecule release for advanced therapeutic applications.

Keywords:

all‐aqueous microfluidics interfacial complexation physiological environment polyelectrolyte sustained release

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Calcium Carbonate Formation in the Presence of Biopolymeric Additives

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Published on: May 14, 2019

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Last Updated: May 9, 2026

Microbiologically Induced Calcite Precipitation Mediated by Sporosarcina pasteurii

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Published on: April 16, 2016

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion

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Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Calcium Carbonate Formation in the Presence of Biopolymeric Additives

Published on: May 14, 2019

Area of Science:

Materials Science
Biotechnology
Nanotechnology

Background:

Polyelectrolyte complexation is a common method for creating drug delivery carriers.
Existing polyelectrolyte carriers suffer from instability and burst release in physiological environments due to swelling.
This limits their therapeutic potential for controlled drug and vaccine delivery.

Purpose of the Study:

To develop novel polyelectrolyte capsules with enhanced stability and controlled release kinetics.
To investigate the use of calcium carbonate precipitation pathways inspired by cellular processes.
To create micro-nano carriers suitable for sustained drug and vaccine delivery.

Main Methods:

Fabrication of micro-nano carriers using all-aqueous microfluidic droplets.
Integration of calcium carbonate precipitation pathways into polyelectrolyte capsules (MICPC).
Characterization of release profiles under physiological conditions.

Main Results:

The developed MICPC demonstrated a precisely controllable and sustained release profile.
Biomolecules were released at an average rate of 3-10% per day, avoiding burst release.
Release kinetics were tunable by adjusting the quantity of synthesized calcium carbonate particles.

Conclusions:

MICPC offers a significant improvement in stability and release control compared to traditional polyelectrolyte capsules.
This approach enhances the potential of polyelectrolyte complex-related materials for drug and vaccine delivery.
The findings provide deeper insights into polyelectrolyte complexation and its applications.