Recent Development on Copper-Sensor and its Biological Applications: A Review.

Area of Science:

• Chemical Sensing
• Coordination Chemistry
• Medicinal Chemistry

Background:

• Metal ion recognition is crucial for clinical, biological, and environmental applications.
• Hydrazones, featuring a N=CH- bond, are known for metal sensing and possess diverse biological activities like anti-cancer and anti-microbial properties.
• Hydrazones serve as ligands for metal ion detection and the generation of metal complexes with therapeutic potential.

Purpose of the Study:

• To review recent advancements (2015-2023) in hydrazones and their copper complexes.
• To explore the significance of copper ions in biological systems.
• To discuss the synthesis, biological activities, mechanisms, and metal sensing capabilities of copper complexes.

Main Methods:

• Literature review of research published between 2015 and 2023.
• Analysis of studies focusing on hydrazone synthesis and characterization.
• Examination of research on copper complex formation and evaluation of their properties.

Main Results:

• Hydrazones and their copper complexes show promise in metal ion sensing.
• Various synthesized copper complexes exhibit significant biological activities.
• The N=CH- bond in hydrazones is key to their metal sensing and biological functions.

Conclusions:

• Hydrazones are versatile ligands for developing advanced chemical sensors.
• Copper complexes derived from hydrazones hold potential for therapeutic applications.
• Continued research into hydrazone-based copper complexes is warranted for enhanced sensing and medicinal uses.