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Diabetic Fibrous Mastopathy: Imaging Features With Histopathologic Correlation
Priya B Patel1, Gloria J Carter2, Wendie A Berg1,3
1University of Pittsburgh Medical Center, Department of Radiology, Pittsburgh, PA, USA.
Journal of Breast Imaging
|February 28, 2024
Summary
Diabetic fibrous mastopathy (DFM) is a rare breast condition in women with diabetes. Diagnosis requires histopathology due to overlapping symptoms with breast cancer.
Area of Science:
- Endocrinology
- Oncology
- Radiology
Background:
- Diabetic fibrous mastopathy (DFM) is a rare, benign fibrotic breast disease.
- It is associated with longstanding, uncontrolled diabetes mellitus.
- DFM commonly affects premenopausal women with dense breasts.
Purpose of the Study:
- To summarize the clinical, imaging, and histopathologic features of DFM.
- To highlight the diagnostic challenges and the need for histopathologic confirmation.
- To differentiate DFM from malignant breast conditions.
Main Methods:
- Review of clinical presentations of DFM.
- Analysis of mammographic, ultrasound (US), and magnetic resonance imaging (MRI) findings.
- Examination of histopathologic features, including stromal and inflammatory changes.
Main Results:
- Clinical presentation includes palpable breast masses, often bilateral.
- Imaging findings (mammography, US, MRI) are nonspecific and can mimic malignancy.
- Histopathology reveals dense collagenous stroma, keloidal features, and chronic inflammation.
Conclusions:
- DFM diagnosis requires histopathologic correlation due to overlapping imaging features with breast cancer.
- Chronic inflammation observed in DFM is also seen in other autoimmune conditions.
- Accurate diagnosis is crucial for appropriate patient management and to exclude malignancy.
