The karyological basis of atypia

There is no distinct DNA-pattern correlating with the degree of dysplasia. Atypical DNA-histograms can be found in morphologically normal smears especially when earlier smears had been suspicious. They can also persist after hysterectomy. In cases of progression aneuploidy and large scatter dominate while in cases of regression the DNA values are concentrated in the polyploid classes. Therefore, persisting atypical histograms signalize an increased risk in cases of dysplasia.