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Murine Fecal Isolation and Microbiota Transplantation
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The Microbiome and Pediatric Transplantation.
Caitlin W Elgarten1,2, Elisa B Margolis3,4, Matthew S Kelly5
1Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Journal of the Pediatric Infectious Diseases Society
|February 28, 2024
Summary
The human microbiome influences transplant success by affecting infection risk and immune responses. Understanding microbiome shifts and therapies can improve outcomes, especially in pediatric transplantation.
Area of Science:
- Microbiology
- Immunology
- Transplantation Science
Background:
- The human microbiome, comprising microbial communities in the body, is increasingly recognized for its impact on host health and disease.
- Microbiome's role in colonization resistance affects infection risk post-transplantation, including multidrug-resistant organism infections.
- The microbiome modulates host immunity through direct interactions and metabolite production, influencing immune tolerance, graft-versus-host disease, and graft rejection.
Conclusions:
- The microbiome is a critical factor in hematopoietic cell and solid organ transplantation outcomes.
- Targeting microbiome modulation offers promising therapeutic avenues for improving transplant success.
- Further research into microbiome-based interventions is crucial, particularly for pediatric patients.
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