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Collaborative Behavioral Teratology Study: programmed data entry and automated test systems.

J Adams, D M Oglesby, H S Ozemek

    Neurobehavioral Toxicology and Teratology
    |November 1, 1985
    PubMed
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    Automated laboratory systems were developed to assess the reliability of behavioral tests in developmental toxicity studies. These systems enhance data collection for toxicological research.

    Area of Science:

    • Neuroscience
    • Toxicology
    • Biomedical Engineering

    Background:

    • Developmental toxicity studies require reliable behavioral assessment methods.
    • Existing methods for evaluating animal behavior in toxicological research can be labor-intensive and prone to variability.
    • Standardization of behavioral testing is crucial for accurate and reproducible results.

    Purpose of the Study:

    • To describe two automated microcomputer systems designed for behavioral testing in developmental toxicity studies.
    • To evaluate the intra- and interlaboratory reliability and sensitivity of behavioral test methods.
    • To support research at the National Center for Toxicological Research (NCTR) and collaborating laboratories.

    Main Methods:

    • System I: Controlled stimulus delivery and recorded behavioral responses in rats during visual discrimination learning, physical landmark, negative geotaxis, and olfactory discrimination tasks using an S-100 bus, Z-80 processor system.

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  • System II: Controlled stimulus delivery and recorded behavioral responses in rats during auditory startle habituation and rodent activity levels in figure 8 mazes using a similar S-100 bus, Z-80 processor system with an A/D I/O board.
  • Both systems utilized operant chambers with stimulus lights, nose-poke apertures, liquid dispensers, and photodiodes, interfaced with microprocessors.

    • Main Results:

    • The described automated systems provide a reliable and sensitive platform for behavioral testing in developmental toxicity.
    • The systems facilitate standardized data acquisition for multiple behavioral paradigms.
    • The implementation at NCTR and collaborating labs demonstrates their practical utility.

    Conclusions:

    • Automated laboratory systems significantly improve the reliability and sensitivity of behavioral assessments in developmental toxicity studies.
    • These systems offer a standardized approach to data collection, crucial for toxicological research.
    • The developed technology supports accurate evaluation of neurobehavioral endpoints in research settings.