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[Bronchial hyperreactivity. III. Clinical manifestations].

E A Valletta, A L Boner

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |May 1, 1985
    PubMed
    Summary

    Bronchial hyperreactivity is frequently observed in respiratory conditions like asthma and cystic fibrosis. This review covers its clinical aspects in children and potential causes.

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    Area of Science:

    • Respiratory Medicine
    • Pediatric Pulmonology
    • Pathophysiology

    Context:

    • Bronchial hyperreactivity is a hallmark of various respiratory diseases, including asthma, chronic bronchitis, and cystic fibrosis.
    • Persistent pulmonary function abnormalities, often including bronchial hyperreactivity, are seen in atopic individuals and children with a history of early-life lung diseases (e.g., laryngotracheobronchitis, bronchiolitis, bronchopulmonary dysplasia).

    Purpose:

    • To review the current literature on the clinical manifestations of bronchial hyperreactivity in children.
    • To explore the potential etiopathogenetic mechanisms underlying bronchial hyperreactivity in pediatric populations.

    Summary:

    • This review synthesizes existing research on bronchial hyperreactivity, focusing on its clinical relevance in children.
    • It examines the link between early-life respiratory insults and the development of persistent bronchial hyperreactivity.
    • The review also delves into the underlying mechanisms contributing to this condition.

    Impact:

    • Provides a comprehensive overview for clinicians and researchers managing pediatric respiratory conditions.
    • Highlights the significance of early-life lung health in the development of bronchial hyperreactivity.
    • Informs future research directions for understanding and treating bronchial hyperreactivity in children.

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