Clinical Impact of the C-reactive Protein-albumin-lymphocyte Index in Post-gastrectomy Patients With Gastric Cancer

Area of Science:

• Oncology
• Surgical Oncology
• Biomarkers

Background:

• Preoperative inflammatory, immune, and nutritional statuses are emerging prognostic factors in gastric cancer (GC) patients post-gastrectomy.
• The C-reactive protein-albumin-lymphocyte (CALLY) index has shown prognostic value in various cancers.
• Clinical significance of the CALLY index in GC patients post-gastrectomy requires further investigation.

Purpose of the Study:

• To prospectively evaluate the preoperative C-reactive protein-albumin-lymphocyte (CALLY) index as a prognostic factor in gastric cancer (GC) patients undergoing gastrectomy.

Main Methods:

• A prospective study included 459 patients undergoing gastrectomy for GC.
• Preoperative CALLY index was calculated from blood test data.
• Associations with clinicopathological factors, overall survival (OS), and recurrence-free survival (RFS) were analyzed.

Main Results:

• The low-CALLY group exhibited older age, higher venous invasion, and more advanced pStage compared to the high-CALLY group.
• The low-CALLY group had significantly worse OS (77.9% vs. 88.9%) and RFS (73.8% vs. 87.1%) post-gastrectomy.
• Multivariate analysis identified a low CALLY score as an independent predictor of poorer OS and RFS.

Conclusions:

• Preoperative CALLY index levels show potential as a valuable prognostic predictor for gastric cancer patients following curative gastrectomy.