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Exercise as medicine in Parkinson's disease
Martin Langeskov-Christensen1,2, Erika Franzén3,4, Lars Grøndahl Hvid5,6
1Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark mach@clin.au.dk.
Journal of Neurology, Neurosurgery, and Psychiatry
|February 28, 2024
Summary
Exercise shows promise as a preventative and disease-modifying therapy for Parkinson's disease (PD). Prescribing exercise as medicine early in PD management could significantly alter clinical practice.
Area of Science:
- Neurology
- Exercise Science
- Preventative Medicine
Background:
- Parkinson's disease (PD) is a progressive neurological disorder with no cure.
- Current treatments offer symptomatic relief but do not halt disease progression and can cause side effects.
- There is a critical need for interventions that can prevent, slow, or mitigate PD.
Purpose of the Study:
- To explore the multifaceted role of exercise in Parkinson's disease management.
- To propose a paradigm shift in how exercise is integrated into early PD treatment.
- To highlight exercise as a potential disease-modifying therapy.
Main Methods:
- Review of existing knowledge base on exercise and Parkinson's disease.
- Analysis of exercise's potential in primary, secondary, and tertiary prevention.
- Synthesis of evidence to support a new treatment approach.
Main Results:
- Exercise is recognized as a protective lifestyle factor (primary prevention).
- Exercise demonstrates potential as a disease-modifying therapy (secondary prevention).
- Exercise is an effective symptomatic treatment (tertiary prevention).
Conclusions:
- Exercise offers fundamental benefits beyond rehabilitation for Parkinson's disease.
- A paradigm shift is proposed, advocating for exercise prescription as medicine.
- Individually prescribed exercise should be an early intervention for Parkinson's disease, alongside conventional medical treatment.
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