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Related Experiment Video

Updated: Jul 2, 2025

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
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How is helping behavior regulated in the brain?

Meng Zhang1, Guohua Chen2, Rongfeng K Hu2

  • 1Department of Psychological Medicine, Zhongshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai 200032, China; Department of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao, Shandong, 266000, China.

Trends in Cognitive Sciences
|February 28, 2024
PubMed
Summary
This summary is machine-generated.

Researchers discovered that the anterior cingulate cortex (ACC) in mice plays a key role in regulating targeted helping behaviors, like allolicking. This finding sheds light on the neural basis of prosocial actions.

Keywords:
allogroomingallolickinganterior cingulate cortexcomfortingmicroendoscopic imagingself-licking

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Area of Science:

  • Neuroscience
  • Animal Behavior
  • Social Cognition

Background:

  • Prosocial behaviors, such as helping, are crucial for social species.
  • The specific neural mechanisms underlying targeted helping remain largely unknown.

Purpose of the Study:

  • To investigate the neural circuits involved in regulating targeted helping behavior in mice.
  • To identify brain regions critical for encoding and controlling prosocial actions.

Main Methods:

  • Utilized observational studies and behavioral assays in a mouse model.
  • Focused on analyzing the role of the anterior cingulate cortex (ACC) in allolicking behavior.

Main Results:

  • Identified a novel function for the anterior cingulate cortex (ACC) in the regulation of targeted helping.
  • Demonstrated the ACC's involvement in both the initiation and modulation of allolicking behavior.

Conclusions:

  • The anterior cingulate cortex (ACC) is a key neural substrate for targeted helping behavior in mice.
  • This research provides insights into the neurobiological underpinnings of prosociality and social decision-making.