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Targeting the NF-κB pathway as a potential regulator of immune checkpoints in cancer immunotherapy

Nasim Ebrahimi1, Al-Hasnawi Rasool Riyadh Abdulwahid2, Atena Mansouri3

  • 1Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran.

Cellular and Molecular Life Sciences : CMLS
|February 28, 2024
PubMed

Insights

Cancer immunotherapy using checkpoint inhibitors like PD1 and CTLA4 can cause autoimmune side effects. Understanding the NF-κB pathway

Area of Science:

  • Oncology and Immunology
  • Molecular Biology

Background:

  • Cancer immunotherapy has advanced with agents targeting immune checkpoints, such as cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell death protein 1 (PD1).
  • Inhibiting these checkpoints can enhance the immune response against cancer but is linked to inflammatory adverse effects resembling autoimmune diseases.

Purpose of the Study:

  • To review the role of the Nuclear Factor kappa B (NF-κB) pathway in tumor promotion.
  • To explore how NF-κB influences inflammatory responses and immune checkpoints in cancer.

Main Methods:

  • Literature review of studies on immune checkpoints and the NF-κB pathway in cancer.

Main Results:

  • The NF-κB pathway acts as a tumor promoter and regulates inflammatory responses.
  • NF-κB signaling impacts the function and expression of various immune checkpoints.

Conclusions:

  • Elucidating the interplay between immune checkpoints and the NF-κB pathway is crucial.
  • This knowledge may improve cancer immunotherapy efficacy and mitigate adverse effects of checkpoint inhibitors.
Keywords:
Immune checkpoint inhibitorsImmune-related adverse eventsImmunooncologyReceptor activator of nuclear factor kappa-Β ligandRegulatory T cells

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