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[Mitral valvular disease secondary to mitral ring calcification: a clinicopathologic study]
Journal of Cardiography
|December 1, 1985
Summary
Mitral ring calcification (MRC) causes significant mitral valvular disease in the elderly, leading to either mitral regurgitation or mitral stenosis. This study details the prevalence, characteristics, and pathological progression of MRC in aged patients.
Area of Science:
- Cardiovascular Pathology
- Geriatric Medicine
- Valvular Heart Disease
Context:
- Mitral ring calcification (MRC) is a common finding in the elderly.
- Its association with significant mitral valvular disease, including mitral regurgitation (MR) and mitral stenosis (MS), requires detailed clinicopathological investigation.
Purpose:
- To determine the prevalence of mitral valvular disease caused by MRC in patients over 60 years old.
- To analyze the clinical and pathological features of MRC-related MR and MS.
- To investigate the progression and distribution of calcification within the mitral valve ring.
Summary:
- A clinicopathological study of 15 autopsy cases (aged >60) with mitral valvular disease due to MRC revealed a prevalence of 0.5% (15/2,800). Nine cases presented with MR and six with MS.
- Phonocardiograms and echocardiograms showed distinct murmur patterns and valve abnormalities. Pathological analysis indicated longer calcification lengths and higher calcification ring ratios (CRR) in MS cases compared to MR cases.
- The study suggests a specific pattern of MRC progression, originating in the posterior mitral leaflet and extending to involve both leaflets and commissures.
Impact:
- Provides crucial data on the prevalence and clinicopathological characteristics of MRC-induced valvular heart disease in the elderly.
- Highlights differences in calcification extent and distribution between mitral regurgitation and mitral stenosis.
- Offers insights into the pathogenetic mechanisms and progression of mitral ring calcification.