Related Experiment Video
Updated: Jul 2, 2025
Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
Published on: October 22, 2016
Transcranial magnetic stimulation therapy for central post-stroke pain: systematic review and meta-analysis
Francisco Gurdiel-Álvarez1,2,3, Víctor Navarro-López2, Sergio Varela-Rodríguez4
1International Doctoral School, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain.
Introduction:
Although rare, central post-stroke pain remains one of the most refractory forms of neuropathic pain. It has been reported that repetitive transcranial magnetic stimulation (rTMS) may be effective in these cases of pain.
Aim:
The aim of this study was to investigate the efficacy of rTMS in patients with central post-stroke pain (CPSP).
Methods:
We included randomized controlled trials or Controlled Trials published until October 3rd, 2022, which studied the effect of rTMS compared to placebo in CPSP. We included studies of adult patients (>18 years) with a clinical diagnosis of stroke, in which the intervention consisted of the application of rTMS to treat CSP.
Results:
Nine studies were included in the qualitative analysis; 6 studies (4 RCT and 2 non-RCT), with 180 participants, were included in the quantitative analysis. A significant reduction in CPSP was found in favor of rTMS compared with sham, with a large effect size (SMD: -1.45; 95% CI: -1.87; -1.03; p < 0.001; I2: 58%).
Conclusion:
The findings of the present systematic review with meta-analysis suggest that there is low quality evidence for the effectiveness of rTMS in reducing CPSP.
Systematic Review Registration:
Identifier (CRD42022365655).
