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Related Experiment Video

Updated: Jul 2, 2025

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
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Causal association between depression and intracranial aneurysms: a bidirectional two-sample Mendelian randomization

Jujiang Wu1, Hao Sun1, Junqiang Ma1,2

  • 1Neurointensive Care Unit, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Frontiers in Neurology
|February 29, 2024
PubMed
Summary

Depression causally increases the risk of intracranial aneurysms (IAs), unruptured IAs (uIA), and subarachnoid hemorrhage (SAH). Unruptured IAs also causally impact depression, but IAs and SAH do not appear to affect depression.

Keywords:
Mendelian randomizationcausal associationdepressionintracranial aneurysmssubarachnoid hemorrhage

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Area of Science:

  • Neurology
  • Psychiatry
  • Genetics

Background:

  • Observational studies suggest a link between depression and intracranial aneurysms (IAs).
  • The causal relationship between depression and IAs remains unclear.
  • This study investigates the bidirectional causal association between depression and IAs.

Purpose of the Study:

  • To determine if depression causes IAs.
  • To determine if IAs cause depression.
  • To assess the causal link between depression and subtypes of IAs, including unruptured IAs (uIA) and subarachnoid hemorrhage (SAH).

Main Methods:

  • Utilized a bidirectional two-sample Mendelian randomization (MR) approach.
  • Employed summary-level data from large genome-wide association studies for depression, IAs, uIA, and SAH.
  • Applied multiple MR methods, including Inverse-Variance Weighted (IVW) as the primary analysis.

Main Results:

  • Genetically predicted depression showed a significant positive association with IAs, uIA, and SAH.
  • Reverse MR analysis indicated a causal effect of genetically predicted uIA on depression.
  • No significant causal relationship was found between IAs or SAH and depression.

Conclusions:

  • This study provides evidence for a causal effect of depression on the development of IAs, uIA, and SAH.
  • A causal impact of uIA on depression was identified.
  • The findings highlight a complex bidirectional relationship between depression and cerebrovascular conditions.