An "all-in-one" treatment and imaging nanoplatform for breast cancer with photothermal nanoparticles
Yuping Fu1, Hongmei Zhang1, Jiahui Ye2
1Division of Breast Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210008 China dg1735099@smail.nju.edu.cn zhangweijie1616@nju.edu.cn.
Abstract:
Drug delivery systems based on nanoparticles still face challenges of low efficacy and an inability to track treatment effects in tumor therapy due to biological barriers. This limitation hinders clinicians' ability to determine treatment effects and proper drug dosages, thus, ultimately impeding the further application and transformation of nanoplatforms. To address this challenge, an all-in-one nanoplatform for therapy and imaging is proposed. The nanoplatform is constructed by using nanoparticles through the co-encapsulation of the photothermal therapeutic agent IR780, the passively targeted drug OA@Fe3O4, and the chemotherapeutic drug paclitaxel. Under the guidance of magnetic navigation, the nanoparticles can enhance local enrichment of the drug, while the luminescence properties of IR780 enable drug tracking at the same time. Remarkably, the nanoparticles exhibit improved photothermal-chemotherapy synergy under magnetic targeting guidance, demonstrating antitumor effects in both in vitro and in vivo experiments. It is demonstrated that the use of these polymeric nanoparticles has significant potential for future biomedical applications and clinical decisions.
Insights
This study introduces a novel nanoparticle system for enhanced cancer therapy and imaging. The nanoplatform combines photothermal therapy, chemotherapy, and magnetic targeting for improved drug delivery and treatment monitoring.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Nanoparticle drug delivery systems face challenges in tumor therapy, including low efficacy and difficulty tracking treatment effects due to biological barriers.
- Current limitations hinder clinical decisions regarding treatment effectiveness and drug dosage, impeding nanoplatform applications.
Purpose of the Study:
- To develop an all-in-one nanoplatform for combined therapy and imaging in cancer treatment.
- To overcome the limitations of conventional nanoparticle drug delivery systems.
Main Methods:
- Co-encapsulation of IR780 (photothermal agent), OA@Fe3O4 (passive targeting), and paclitaxel (chemotherapy) into nanoparticles.
- Utilizing magnetic navigation for enhanced local drug enrichment.
- Leveraging IR780 luminescence for simultaneous drug tracking.
Main Results:
- The nanoplatform demonstrated enhanced local drug enrichment via magnetic navigation.
- IR780's luminescence enabled real-time drug tracking.
- Significant synergistic photothermal-chemotherapy effects were observed under magnetic targeting.
- Effective antitumor activity was confirmed in both in vitro and in vivo models.
Conclusions:
- The developed polymeric nanoparticles show significant potential for advanced biomedical applications.
- This nanoplatform offers a promising approach for improved cancer therapy and clinical decision-making.
More Related Videos
09:01Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
09:51One Minute, Sub-One-Watt Photothermal Tumor Ablation Using Porphysomes, Intrinsic Multifunctional Nanovesicles
Published on: September 17, 2013