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Genotoxicity induced by endodontic sealers: A systematic review
Thiago Guedes Pinto1, Ana Claudia Muniz Renno1, Jean Nunes Dos Santos2
1Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Santos, SP, Brazil.
The Saudi Dental Journal
|February 29, 2024
Summary
Endodontic sealers may cause DNA damage, with resin-based materials showing the highest genotoxic potential. This systematic review clarifies the genotoxicity of various dental sealers in vitro and in vivo.
Area of Science:
- Dental Materials Science
- Molecular Biology
- Toxicology
Background:
- Endodontic sealers are crucial for root canal therapy.
- Understanding their potential genotoxicity is vital for patient safety.
- Previous research has yielded varied results regarding sealer-induced DNA damage.
Purpose of the Study:
- To systematically review and elucidate whether endodontic sealers can induce DNA damage.
- To assess the genotoxic potential of various endodontic sealer types.
- To clarify the extent to which endodontic sealers cause DNA injury in oral tissues.
Main Methods:
- Systematic review conducted following PRISMA 2020 guidelines.
- Inclusion of 23 selected studies evaluating endodontic sealers.
- Analysis of genotoxicity assays, material types, and concentration levels.
Main Results:
- Most endodontic sealers demonstrated genotoxic potential.
- Resin-based sealers were identified as the most potentially genotoxic.
- Genotoxicity outcomes were influenced by assay type, material, and concentration.
Conclusions:
- Endodontic sealers can act as genotoxic agents.
- Resin-based sealers warrant particular attention due to their genotoxic potential.
- Further clarification on sealer-induced DNA damage in oral tissues is provided.
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