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Updated: Jul 2, 2025
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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Exploring the Relation Between Interstitial Lung Diseases and Chronic Periodontitis: A Systematic Review
Prerna S Hirkane1, Umesh P Verma1, Ajay K Verma2
1Periodontology, King George's Medical University, Lucknow, IND.
Cureus
|February 29, 2024
Summary
This systematic review found mounting evidence linking chronic periodontitis and interstitial lung diseases. Further research is needed to fully understand the microbial, genetic, and environmental connections between these conditions.
Area of Science:
- Oral Medicine
- Pulmonology
- Systematic Reviews
Background:
- Chronic periodontitis is a prevalent oral inflammatory condition.
- Interstitial lung diseases (ILDs) are a heterogeneous group of lung disorders.
- Potential links between systemic and oral health are increasingly recognized.
Purpose of the Study:
- To systematically review and synthesize evidence on the association between chronic periodontitis and ILDs.
- To explore potential shared mechanisms including microbial, biomarker, genetic, and environmental factors.
- To assess the current state of research on this comorbidity.
Main Methods:
- Systematic review conducted from 2000-2021.
- Searches performed in PubMed-Medline, Google Scholar, and Cochrane databases.
- Included 42 studies meeting predefined inclusion criteria, following PRISMA guidelines.
Main Results:
- Extracted data indicates growing evidence for an association between chronic periodontitis and ILDs.
- The review highlights potential shared risk factors and pathobiological pathways.
- Identified studies explored various levels of association, from microbial to environmental.
Conclusions:
- There is a growing body of evidence suggesting a link between chronic periodontitis and interstitial lung diseases.
- The findings support the need for further investigation into the underlying mechanisms.
- This review underscores the potential impact of periodontal health on respiratory outcomes.
Keywords:
antioxidantsbiomarkerschronic periodontitisgenetic associationinterstitial lung diseasesmicrobessmokingMore Related Videos
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