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Updated: Jul 2, 2025

Knee Arthrocentesis in Adults
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Hyperacute Serum and Knee Osteoarthritis.

Ashim Gupta1,2,3,4, Adarsh Aratikatla5

  • 1Orthopaedics and Regenerative Medicine, Regenerative Orthopaedics, Noida, IND.

Cureus
|February 29, 2024
PubMed
Summary

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Hyperacute serum (HS) shows promise for managing knee osteoarthritis (OA) by improving chondrocyte viability, reducing pain, and enhancing function. Further research is needed to confirm its safety and efficacy in clinical practice.

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biologics

Background:

  • Knee osteoarthritis (OA) is a prevalent degenerative joint disease with increasing incidence due to aging populations and rising obesity rates.
  • Current OA treatments have limitations, driving the need for novel therapeutic approaches.
  • Regenerative medicine, utilizing orthobiologics like autologous peripheral blood-derived hyperacute serum (HS), has emerged as a potential treatment modality for knee OA.

Purpose of the Study:

  • To qualitatively review in vitro, pre-clinical, and clinical studies on the application of hyperacute serum (HS) for knee osteoarthritis (OA).
  • To assess the potential safety and efficacy of HS in managing knee OA symptoms and improving joint function.

Main Methods:

  • A qualitative review of existing literature, including seven in vitro studies and one clinical study, investigating HS for knee OA.
Keywords:
autologous bloodblood-derived biologicshyperacute serumknee osteoarthritisorthobiologicsosteoarthritisplatelet-rich fibrinplatelet-rich plasmaregenerative medicineserum from platelet-rich fibrin

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  • Analysis of reported outcomes related to chondrocyte viability, pain reduction, inflammation control, and functional improvement.

    • Main Results:

    • In vitro and clinical findings suggest that HS administration is potentially safe and efficacious for knee OA.
    • Observed benefits include increased osteoarthritic chondrocyte viability, reduced pain and inflammation, and improved joint function in patients.
    • The reviewed studies indicate a positive trend in managing knee OA with HS.

    Conclusions:

    • Hyperacute serum (HS) demonstrates potential as a safe and effective biologic treatment for knee osteoarthritis (OA).
    • Further rigorous pre-clinical research is necessary to elucidate the mechanism of action of HS.
    • Large-scale, multi-center randomized controlled trials with extended follow-up are required to definitively establish the clinical utility of HS for knee OA management.