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Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative

Joel Rodriguez Troncoso1, Umme Marium Mim1, Jesse D Ivers1

  • 1Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR 72701, USA.

Biomedical Optics Express
|February 29, 2024
PubMed
Summary
This summary is machine-generated.

Diffuse reflectance spectroscopy can distinguish between aggressive and indolent breast tumors by analyzing optical properties. This noninvasive technique shows potential for evaluating tumor biology and metastasis capability.

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Area of Science:

  • Biomedical Optics
  • Cancer Research
  • Translational Oncology

Background:

  • The invasion-metastasis cascade is a complex process.
  • Distinguishing between indolent and aggressive tumors is crucial for effective treatment.
  • Noninvasive methods for assessing tumor biology are highly desirable.

Purpose of the Study:

  • To utilize diffuse reflectance spectroscopy (DRS) to quantify optical parameters in isogenic murine breast cancer models.
  • To correlate optical properties with the metastatic potential of different tumor cell lines.
  • To explore the potential of DRS and machine learning for noninvasive tumor classification.

Main Methods:

  • Employing diffuse reflectance spectroscopy to measure tissue absorption and scattering parameters.
  • Analyzing tumors from four isogenic murine breast cancer cell lines (4T1, 4T07, 168FARN, 67NR) with varying metastatic capabilities.
  • Applying supervised learning statistical approaches for tumor differentiation and classification.

Main Results:

  • Indolent 67NR tumors exhibited lower tissue scattering, higher hemoglobin concentration, and lower vascular oxygenation compared to aggressive 4T1 tumors.
  • Supervised learning models accurately differentiated between tumor groups based on optical properties.
  • Investigated optical changes in 4T1 tumors upon inhibition of metastasis-promoting genes.

Conclusions:

  • Diffuse reflectance spectroscopy can noninvasively evaluate tumor biology.
  • Optical properties measured by DRS can discriminate between indolent and aggressive breast tumors.
  • DRS holds promise for assessing the metastatic potential of tumors.