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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

366
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

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Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
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Updated: Jul 2, 2025

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells
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Considerations for developing mitochondrial transplantation techniques for individualized medicine.

Kit Neikirk1, Dominique C Stephens1,2, Heather K Beasley1

  • 1Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

Biotechniques
|February 29, 2024
PubMed
Summary

Mitochondrial transplantation shows promise for treating diseases linked to mitochondrial dysfunction. This review emphasizes critical quality control measures for successful mitochondrial transplantation therapies.

Area of Science:

  • Cell biology
  • Regenerative medicine
  • Biotechnology

Background:

  • Mitochondrial dysfunction is implicated in numerous human diseases.
Keywords:
individualized medicinemitochondria diseasesmitochondria transfermitochondria transplantation

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  • Mitochondrial transplantation is an emerging therapeutic strategy.
  • Ensuring the quality of transplanted mitochondria is crucial for efficacy.