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Emerging roles of nerve-bone axis in modulating skeletal system
Jingya Li1, Zhuoyuan Zhang1, Jinru Tang1
1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Medicinal Research Reviews
|February 29, 2024
Summary
The nerve-bone axis, involving nerve-bone crosstalk, significantly impacts bone health and repair. Understanding this connection offers new therapeutic strategies for skeletal regeneration and neuromodulation.
Area of Science:
- Skeletal neurobiology
- Bone physiology and pathophysiology
Background:
- Emerging evidence highlights the critical role of bone innervation in skeletal health.
- The nerve-bone axis is a key focus in understanding skeleton-nerve system interactions.
Purpose of the Study:
- To review novel research on the nerve-bone axis.
- To deepen the understanding of neuromodulation's role in skeletal physiology and repair.
Main Methods:
- Literature review of preclinical and clinical investigations.
- Analysis of studies on peripheral nerve involvement in bone metabolism and fracture healing.
Main Results:
- Peripheral nerves modulate bone growth, development, and fracture healing through secreted factors.
- Identified neural pathways significantly alter bone cell biology.
- Neuromodulation inspires novel drug delivery systems for bone regeneration.
Conclusions:
- The nerve-bone axis is crucial for skeletal homeostasis and repair.
- Understanding nerve-bone crosstalk can lead to clinical applications in skeletal tissue regeneration.
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