Related Experiment Video

Updated: Jul 2, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Systems genetics analysis reveals the common genetic basis for pain sensitivity and cognitive function

Fuyi Xu1, Anran Chen2, Shuijing Pan1

  • 1Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai, China.

CNS Neuroscience & Therapeutics
|February 29, 2024
PubMed
Summary

Genetic background influences pain sensitivity and cognitive function. Ring finger protein 20 (Rnf20) and PI3K-Akt signaling are key molecular mechanisms linking these traits.

Keywords:
Rnf20BXD micecognitionhippocampuspain sensitivity

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