Concentration of D-propranolol in cervico-vaginal mucus: targeting of a novel spermicide

It may be possible to develop new contraceptives that can be administered by mouth and will exert their effects after concentration in cervico-vaginal mucus. D-Propranolol was administered in 80 mg doses by mouth to six healthy female volunteers. Samples of blood plasma and cervico-vaginal mucus were obtained before and on six occasions up to 24 hours after drug ingestion. D-Propranolol was concentrated in cervico-vaginal mucus. No changes in blood pressure, pulse, or forced expiratory peak flow (FEPF) were observed.