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Immunohistochemical expression of vimentin, E-cadherin, and CD45 in natural cases of canine cutaneous round tumors

  • 0Alexandria University, Faculty of Veterinary Medicine, Pathology Department, Edfina, Egypt.
Brazilian Journal of Biology = Revista Brasleira De Biologia +

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February 29, 2024

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February 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Canine round cell tumors are common skin neoplasms. Transmissible venereal tumors were most frequent, followed by cutaneous histiocytomas and histiocytic sarcoma, aiding in diagnosis.

Area Of Science

  • Veterinary Pathology
  • Dermatology
  • Oncology

Background

  • Round cell tumors are prevalent cutaneous lesions in dogs.
  • Understanding their frequency and characteristics is crucial for diagnosis and treatment.

Purpose Of The Study

  • To investigate the frequency, gross, and pathological characteristics of canine cutaneous round cell tumors.
  • To evaluate immunohistochemical markers (vimentin, E-cadherin, CD45) for differential diagnosis.
  • To analyze prevalence in relation to breed, sex, and age.

Main Methods

  • Histopathological examination of 64 tumorous dogs.
  • Classification of neoplasms based on age, sex, breed, and location.
  • Immunohistochemical staining for vimentin, E-cadherin, and CD45.

Main Results

  • Transmissible venereal tumors (48 cases) were the most common round cell tumor.
  • Cutaneous histiocytomas (12 cases) and histiocytic sarcoma (4 cases) were also identified.
  • Immunohistochemistry showed distinct marker expression patterns for each tumor type.

Conclusions

  • Canine transmissible venereal tumor is the most frequent cutaneous round cell tumor.
  • Histopathological morphology combined with immunohistochemical findings is essential for definitive diagnosis.
  • Immunohistochemistry aids in differentiating canine cutaneous round cell neoplasms.