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Theranostic Fluorescent Probes.

Amit Sharma1, Peter Verwilst2, Mingle Li3

  • 1Amity School of Chemical Sciences, Amity University Punjab, Sector 82A, Mohali 140 306, India.

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|February 29, 2024
PubMed
Summary
This summary is machine-generated.

Theranostic fluorescent probes offer spatiotemporal control for drug delivery, signaling release with fluorescence. This review covers recent advancements, particularly for tumor microenvironments and other diseases.

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Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Drug Delivery Systems

Background:

  • Theranostic fluorescent probes integrate imaging and therapeutic functions for precise drug delivery.
  • Recent years have seen a significant increase in research publications on theranostic fluorescent probes.
  • These probes typically consist of a fluorophore linked to a masked drug, releasing it upon specific stimuli.

Purpose of the Study:

  • To review recent advancements in theranostic fluorescent probes.
  • To focus on probes activated within tumor microenvironments.
  • To summarize the development of probes for neurodegenerative diseases and antibacterial applications.

Main Methods:

  • Review of recent scientific literature on theranostic fluorescent probes.
  • Analysis of probe designs, including small-molecule systems and nanomaterials.
  • Highlighting probes activated by intrinsic and extrinsic stimuli.

Main Results:

  • Theranostic fluorescent probes enable spatiotemporal information gain and control in drug delivery.
  • Fluorescence signaling indicates drug release, serving as a spatiotemporal marker.
  • Fluorophores facilitate therapeutic applications like photodynamic, photothermal, and sonodynamic therapies.

Conclusions:

  • Theranostic fluorescent probes show diverse designs and significant potential for clinical impact.
  • Focus on tumor microenvironment-activated probes is a key research area.
  • Applications extend to neurodegenerative diseases and antibacterial treatments, showcasing broad utility.