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Identification and α-glucosidase inhibitory activity evaluation of two new coumarins derived from Mansonia gagei J.
Huong Thi Thu Le1, Yusuke Hioki2, Duy Vu Nguyen3
1Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam.
Abstract:
Five coumarins were isolated from the heartwood of Mansonia gagei, which included two newly discovered compounds, namely 11-hydroxypopulene E (1) and mansorin D (2), along with three previously identified compounds. The structures were determined through the utilisation of comprehensive spectroscopic data, ECD calculations, and a thorough comparison with existing literature data. The α-glucosidase inhibitory activities of all isolated compounds were assessed in yeast. Out of the compounds tested, compound 2 exhibited the most significant activity, displaying a percentage inhibition of 34.33% at a concentration of 200 μM.
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