Related Experiment Video
Updated: May 5, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
DEAR model in overweight endometrial cancer patients undergoing fertility-sparing treatment: A randomized controlled
YiQian Chen1, JingYing Yang2, Yu Wan3
1Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China; Beijing Health Vocational College, Beijing, China.
Objective:
To evaluate the effects of DEAR weight management in overweight patients undergoing fertility-sparing treatment for endometrial cancer or atypical hyperplasia.
Methods:
Women with endometrial cancer or atypical hyperplasia who received fertility-sparing treatment and had a body mass index of >25 kg/m2 were randomly allocated to the DEAR (DEAR weight management) and control (self weight management) groups. Body morphology and composition, glycolipid metabolism, and tumor outcomes were assessed in both groups before and at 3 and 6 months after intervention.
Results:
Overall, 72 subjects were included (36 in each group). Following intervention, the DEAR group showed significantly lower median body weight (69.45 vs. 78.05), body mass index (26.19 vs. 29.15), lipid accumulation index (29.21 vs. 57.86), body fat mass (24.00 vs. 29.30), visceral fat area (112.5 vs. 133.3), and glycolipid metabolic indices (except high density lipoprotein) than the control group (P < 0.05) and showed a decreasing trend. The test group achieved significantly higher complete remission (88.46% vs. 57.14%; P < 0.05); the time to complete remission did not differ significantly (P > 0.05).
Conclusions:
DEAR weight management can improve the studied parameters and complete remission rates in this population.
Registration:
NCT06169449.
