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Published on: June 9, 2023
Decoding cell death signalling: Impact on the response of breast cancer cells to approved therapies
Lama Lozon1, Wafaa S Ramadan2, Rawan R Kawaf3
1College of Medicine, University of Sharjah, Sharjah 27272, United Arab Emirates; Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates.
Abstract:
Breast cancer is a principal cause of cancer-related mortality in female worldwide. While many approved therapies have shown promising outcomes in treating breast cancer, understanding the intricate signalling pathways controlling cell death is crucial for optimizing the treatment outcome. A growing body of evidence has unveiled the aberrations in multiple cell death pathways across diverse cancer types, highlighting these pathways as appealing targets for therapeutic interventions. In this review, we provide a comprehensive overview of the current state of knowledge on the cell death signalling mechanisms with a particular focus on their impact on the response of breast cancer cells to approved therapies. Additionally, we discuss the potentials of combination therapies that exploit the synergy between approved drugs and therapeutic agents targeting modulators of cell death pathways.
Insights
Understanding cell death pathways is key to improving breast cancer treatment. This review explores how targeting these pathways, alongside approved therapies, can enhance treatment effectiveness for breast cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Cell Biology
Background:
- Breast cancer remains a leading cause of cancer mortality globally.
- Approved therapies offer benefits, but optimizing outcomes requires deeper insight into cell death mechanisms.
- Aberrations in cell death pathways are common in cancers, presenting therapeutic opportunities.
Purpose of the Study:
- To review current knowledge on cell death signaling mechanisms in breast cancer.
- To analyze the impact of these pathways on breast cancer cell response to therapies.
- To explore combination therapy strategies targeting cell death modulators.
Main Methods:
- Literature review of cell death signaling pathways.
- Analysis of existing data on breast cancer treatment response.
- Discussion of therapeutic strategies and combination approaches.
Main Results:
- Cell death pathways significantly influence breast cancer treatment efficacy.
- Targeting specific cell death mechanisms can overcome therapeutic resistance.
- Combination therapies show potential for synergistic effects.
Conclusions:
- A comprehensive understanding of cell death signaling is vital for advancing breast cancer therapy.
- Targeting cell death pathways offers promising avenues for novel therapeutic interventions.
- Exploiting combination strategies may improve patient outcomes in breast cancer treatment.
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