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Updated: Jul 1, 2025

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Epileptic seizures and abnormal tooth development as primary presentation of pseudohypoparathyroidism type 1B
Anne-Marie Van der Biest1,2, Harald Jüppner3, Corina Andreescu4
1Endocrinology, UZ Brussel, Brussel, Belgium annemarie.vanderbiest@gmail.com.
Abstract:
Pseudohypoparathyroidism (PHP) is a rare genetic disorder characterised by a non-functioning PTH. Usually, the diagnosis is made following (symptomatic) hypocalcaemia. We describe a case in which epileptic seizures and abnormalities in dental development were the main clinical manifestation of PHP type 1B. This case demonstrates the importance of screening for hypocalcaemia in patients with de novo epileptic seizures. In addition, antiepileptic medications themselves may interfere with calcium-phosphate metabolism, causing or aggravating a hypocalcaemia as well. By correcting the calcium level, a resolution of these symptoms could be obtained.
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