Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arteries of the Lower Limbs01:24

Arteries of the Lower Limbs

189
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
189
Seizures: Classification01:13

Seizures: Classification

347
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
347
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

90
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
90
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

345
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
345
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

399
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
399

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excess EEG beta-band oscillations in Dup15q syndrome correlate with clinical severity.

Translational psychiatry·2026
Same author

Editorial: Psychiatric insights in genetic and chromosomal disorders.

Frontiers in psychiatry·2026
Same author

A two-step temporal data augmentation and supervised learning framework for predicting autism diagnosis at 36 months in patients with tuberous sclerosis complex.

Computers in biology and medicine·2026
Same author

NIH-Funded Pediatric Research.

JAMA pediatrics·2026
Same author

Serum and cerebral folate are normal in Down Syndrome Regression Disorder.

Molecular autism·2026
Same author

Neurodevelopmental Outcomes From the PREVeNT Trial.

Pediatric neurology·2025
Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026
Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026
Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026
Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026
Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026
Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2025

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.1K

Autism and Epilepsy.

Jamie K Capal1, Shafali S Jeste2

  • 1Department of Neurology, University of North Carolina at Chapel Hill, 170 Manning Drive, CB 7025, Chapel Hill, NC 27599, USA.

Pediatric Clinics of North America
|February 29, 2024
PubMed
Summary
This summary is machine-generated.

Autism spectrum disorder (ASD) frequently co-occurs with epilepsy. Identifying epilepsy risk factors in ASD, such as developmental delay and genetic conditions, is crucial for timely diagnosis and referral to specialists.

Keywords:
Autism spectrum disorderEpilepsyGenetics

More Related Videos

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

9.6K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

970

Related Experiment Videos

Last Updated: Jul 1, 2025

Pentylenetetrazole-Induced Kindling Mouse Model
07:06

Pentylenetetrazole-Induced Kindling Mouse Model

Published on: June 12, 2018

33.1K
Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

9.6K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

970

Area of Science:

  • Neurology
  • Genetics
  • Developmental Pediatrics

Background:

  • Epilepsy is a common comorbidity in individuals with autism spectrum disorders (ASDs).
  • Understanding risk factors is essential for early detection and management of seizures in this population.

Purpose of the Study:

  • To highlight the high prevalence of epilepsy in ASD.
  • To emphasize the importance of clinical suspicion and neurological referral for seizures in ASD patients.
  • To underscore the value of genetic testing, particularly in co-occurring ASD and epilepsy.

Main Methods:

  • This abstract summarizes clinical observations and recommendations regarding epilepsy in ASD.
  • It emphasizes the role of risk factor identification and diagnostic procedures.

Main Results:

  • Individuals with ASD have a higher risk of epilepsy.
  • Developmental delay, intellectual disability, female sex, age, and genetic conditions are identified risk factors.
  • Genetic testing is particularly informative in children with both ASD and epilepsy.

Conclusions:

  • A high index of suspicion for seizures is warranted in individuals with ASD.
  • Prompt referral to a neurologist is recommended if seizures are suspected.
  • Genetic testing should be considered for all children with ASD, with increased yield in those also diagnosed with epilepsy.