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  3. Focal Brain Lesions Causing Acquired Amusia Map To A Common Brain Network
  1. Home
  3. Focal Brain Lesions Causing Acquired Amusia Map To A Common Brain Network

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Focal Brain Lesions Causing Acquired Amusia Map to a Common Brain Network

Aleksi J Sihvonen1,2,3,4, Michael A Ferguson5,6,7, Vicky Chen8

  • 1Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland aleksi.sihvonen@helsinki.fi.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|February 29, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study identifies a distinct brain network for processing music, separate from language networks. Lesion network mapping reveals this network, offering potential targets for treating amusia (neurologic music processing deficit).

Keywords:
amusiaaphasialanguagelesion network mappingmusicstroke

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Area of Science:

  • Neuroscience
  • Neurology
  • Cognitive Science

Background:

  • Amusia, a deficit in music processing, arises from lesions in various brain areas, often co-occurring with aphasia.
  • The specific neural networks underlying amusia remain unclear due to heterogeneous lesion locations.

Purpose of the Study:

  • To identify the distinct neural networks responsible for amusia using lesion network mapping.
  • To differentiate the neural substrates of music processing from language processing.

Main Methods:

  • Systematic literature review of case reports on lesion-induced amusia.
  • Lesion network mapping applied to case reports and a prospective cohort of 97 stroke patients.
  • Structural brain imaging and assessment of music perception and language abilities.

Main Results:

  • Lesions causing amusia converged on a common brain network, primarily involving bilateral temporoparietal and insular cortices, precentral gyrus, and cingulum.
  • In the prospective cohort, amusia lesions mapped to a network centered on the right superior temporal cortex, distinct from the aphasia network.
  • Structural changes (gray and white matter reduction) in the amusia network correlated with amusia severity.

Conclusions:

  • Despite varied lesion sites, a common, distinct brain network underlies music processing.
  • This research differentiates the neural basis of music from language, identifying potential targets for amusia treatment via noninvasive brain stimulation.